在伦敦，富时100指数周三下跌43点，跌幅0.50%。葛兰素史克（-5.00%）、能多洁（-3.57%）和Segro（-2.50%）领跌。涨幅最大的是Entain（3.05%）、洲际酒店（2.14%）和保诚（1.84%）。

In London, the FTSE 100 Index decreased 43 points or 0.50 percent on Wednesday. Losses were driven by GlaxoSmithKline (-5.00%), Rentokil Initial (-3.57%) and Segro (-2.50%). Biggest rises came from Entain (3.05%), Intercontinental Hotels (2.14%) and Prudential (1.84%).

标准普尔全球英国建筑业采购经理人指数从3月份的46.4上升至2025年4月的46.6，这是连续第四个月收缩，商业不确定性推迟了新项目，导致新订单和人员水平进一步下降。土木工程是最弱的部门（43.1），而住宅建筑显示出弹性，是2025年迄今为止下降幅度最小的部门（47.1）。由于对英国经济前景的担忧日益加剧，商业工作也大幅下降（45.5）。采购活动以近五年来最快的速度下降，尽管供应商交货时间连续第三个月有所改善。尽管需求下降，但由于材料和工资成本上升，成本压力仍然很高。裁员仍在继续，但略有放缓。尽管如此，由于对未来住宅项目的乐观情绪，商业信心升至2024年12月以来的最高水平。

The S&P Global UK Construction PMI rose to 46.6 in April 2025 from 46.4 in March, the fourth straight month of contraction, with business uncertainty delaying new projects and causing further drops in new orders and staffing levels. Civil engineering was the weakest sector (43.1), while residential construction showed resilience with the mildest decline of 2025 so far (47.1). Commercial work also fell sharply (45.5), amid growing concerns over the UK’s economic outlook. Purchasing activity dropped at its fastest rate in nearly five years, though supplier delivery times improved for the third month running. Despite falling demand, cost pressures remained high due to rising material and payroll costs. Job cuts continued but slowed slightly. Nonetheless, business confidence rose to its highest level since December 2024, driven by optimism for future residential projects.

英镑：贸易协议可能有所帮助–ING。英镑交易稳定，但本月政治应该是支持性的。ING外汇分析师Chris Turner指出，我们已经看到昨天宣布了一项新的英印贸易协议，但越来越多的人猜测本周可能会达成美英贸易协议。

GBP: Trade deals can help – ING.Sterling is trading steadily, but politics should be supportive this month. We've already seen a new UK-Indian trade deal announced yesterday, but speculation is rising that a US-UK trade deal could be reached this week, ING's FX analyst Chris Turner notes.

富时100指数周三小幅下跌，在连续16个交易日上涨后暂停。制药巨头阿斯利康（AstraZeneca）和葛兰素史克（GSK）的大幅下跌打压了投资者情绪，这两家公司分别下跌了近2.5%和4%以上，此前美国市场对维奈·普拉萨德（Vinay Prasad）的任命产生了负面反应。尽管一些支持性的企业更新，但整体市场情绪喜忧参半。BAE系统公司在全球国防需求强劲的情况下重申了其前景，Trainline的利润超出了预期。在政策方面，英国和美国官员正在进行密集会谈，旨在达成一项新的经济协议以降低关税，这增加了减少贸易摩擦的希望。这些讨论是在英国最近与印度达成贸易协议之后进行的，这是英国脱欧以来最大的贸易协议。与此同时，随着美中贸易谈判在瑞士恢复，全球市场仍持谨慎态度，此举旨在缓和一直使全球经济前景紧张的紧张局势。

The FTSE 100 edged lower on Wednesday, pausing after 16 consecutive sessions of gains. Investor sentiment was weighed down by sharp losses in pharmaceutical giants AstraZeneca and GSK, which dropped nearly 2.5% and over 4%, respectively, following negative reaction in US markets to the appointment of Vinay Prasad. The broader market mood was mixed despite some supportive corporate updates. BAE Systems reaffirmed its outlook amid strong global defense demand, and Trainline exceeded profit expectations. On the policy front, UK and US officials are in intensive talks aimed at reaching a new economic deal to ease tariffs, raising hopes of reduced trade frictions. These discussions follow the UK’s recent trade agreement with India, its biggest since Brexit. Meanwhile, global markets remain cautious as US-China trade negotiations resume in Switzerland, a move aimed at cooling tensions that have been straining the global economic outlook.